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 Quantitative proliferation dynamics and random chromosome segregation of hair follicle stem cells
Employing an elegant new quantitative approach to study the proliferation dynamics of hair follicle stem cells in vivo, Tudorita Tumbar and coworkers address two important and controversial concepts in stem cell biology. Their data make a strong case in favour of the infrequent division model, but not for selective chromosome retention in stem cells.
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A Wingless and Notch double-repression mechanism regulates G1–S transition in the Drosophila wing
Wing development serves as a paradigm for understanding the cooperation between signaling pathways in tissue patterning. Herranz et al. now present an integrated picture of how Notch and Wingless are linked to the key cell cycle regulators dMyc, E2F, and the bantam miRNA.
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| This collection of eight review articles - Focus on Quality Control - highlights different aspects of cellular quality control and their potential relevance for human diseases. Topics include mitochondrial and ER quality control, protein folding and degradation; as well as quality control in RNA and DNA metabolism. The reviews will be printed in three subsequent regular issues of The EMBO Journal starting with the second issue in January 2008 (27.2). These online review articles include downloadable figures for teaching purposes and links to relevant research articles published recently in The EMBO Journal and other Nature Publishing Group titles. |
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