This collection of eight review articles - Focus on Quality Control - highlights different aspects of cellular quality control and their potential relevance for human diseases. Topics include mitochondrial and ER quality control, protein folding and degradation; as well as quality control in RNA and DNA metabolism. The reviews will be printed in three subsequent regular issues of The EMBO Journal starting with the second issue in January 2008 (27.2). These online review articles include downloadable figures for teaching purposes and links to relevant research articles published recently in The EMBO Journal and other Nature Publishing Group titles.
Editor's introduction
Quality control in an unreliable world
Pernille Rørth
doi: 10.1038/sj.emboj.7601973
The EMBO Journal 27, 303-305
Focus on Quality Control
Quality control of mitochondria: protection against neurodegeneration and ageing
Takashi Tatsuta and Thomas Langer
doi: 10.1038/sj.emboj.7601972
The EMBO Journal 27, 306-314
Protein quality control in the early secretory pathway
Tiziana Anelli and Roberto Sitia
doi: 10.1038/sj.emboj.7601974
The EMBO Journal 27, 315-327
Chaperones in control of protein disaggregation
Krzysztof Liberek, Agnieszka Lewandowska and Szymon Zi
tkiewicz
doi: 10.1038/sj.emboj.7601970
The EMBO Journal 27, 328-335
The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases
Konstanze F Winklhofer, Jörg Tatzelt and Christian Haass
doi: 10.1038/sj.emboj.7601930
The EMBO Journal 27, 336-349
Messenger RNA regulation: to translate or to degrade
Ann-Bin Shyu, Miles F Wilkinson
doi: 10.1038/sj.emboj.7601977
The EMBO Journal 27, 471-481
3' end mRNA processing: molecular mechanisms and implications for health and disease
Sven Danckwardt, Matthias W Hentze and Andreas E Kulozik
doi: 10.1038/sj.emboj.7601932
The EMBO Journal 27, 482–498
Quality control of DNA break metabolism: in the 'end', it's a good thing
Roland Kanaar, Claire Wyman and Rodney Rothstein
doi: emboj.2008.11
The EMBO Journal 27, 581–588
DNA-damage repair; the good, the bad, and the ugly
Razqallah Hakem
doi: 10.1038/emboj.2008.15
The EMBO Journal 27, 589–605