See also: Protein Quality Control
The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90
Sebastian K Wandinger, Michael H Suhre, Harald Wegele and Johannes Buchner
doi: 10.1038/sj.emboj.7600930
The EMBO Journal 25, 367-376
The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Aβ generation in vivo
Arames Crameri, Elisa Biondi, Katrin Kuehnle, Dieter Lütjohann, Karin M Thelen, Simona Perga, Carlos G Dotti, Roger M Nitsch, Maria Dolores Ledesma and M Hasan Mohajeri
doi: 10.1038/sj.emboj.7600938
The EMBO Journal 25, 432-443
Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways
Tommer Ravid, Stefan G Kreft and Mark Hochstrasser
doi: 10.1038/sj.emboj.7600946
The EMBO Journal 25, 533-543
Molecular chaperones and the assembly of the prion Sup35p, an in vitro study
Joanna Krzewska and Ronald Melki
doi: 10.1038/sj.emboj.7600985
The EMBO Journal 25, 822-833
Adaptor protein controlled oligomerization activates the AAA+ protein ClpC
Janine Kirstein, Tilman Schlothauer, David A Dougan, Hauke Lilie, Gilbert Tischendorf, Axel Mogk, Bernd Bukau and Kür
ad Turgay
doi: 10.1038/sj.emboj.7601042
The EMBO Journal 25, 1481-1491
An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis
Annett Boeddrich, Sébastien Gaumer, Annette Haacke, Nikolay Tzvetkov, Mario Albrecht, Bernd O Evert, Eva C Müller, Rudi Lurz, Peter Breuer, Nancy Schugardt, Stephanie Stephanie Pla
mann, Kexiang Xu, John M Warrick, Jaana Suopanki, Ullrich Wüllner, Ronald Frank, Ulrich F Hartl, Nancy M Bonini and Erich E Wanker
doi: 10.1038/sj.emboj.7601043
The EMBO Journal 25, 1547-1558
Glycine-alanine repeats impair proper substrate unfolding by the proteasome
Martin A Hoyt, Judith Zich, Junko Takeuchi, Mingsheng Zhang, Cedric Govaerts and Philip Coffino
doi: 10.1038/sj.emboj.7601058
The EMBO Journal 25, 1720-1729
The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment
Robert Gauss, Thomas Sommer and Ernst Jarosch
doi: 10.1038/sj.emboj.7601088
The EMBO Journal 25, 1827-1835
An aging pathway controls the TrkA to p75NTR receptor switch and amyloid β-peptide generation
Claudio Costantini, Heidi Scrable and Luigi Puglielli
doi: 10.1038/sj.emboj.7601062
The EMBO Journal 25, 1997-2006
Retrovirus infection strongly enhances scrapie infectivity release in cell culture
Pascal Leblanc, Sandrine Alais, Isabel Porto-Carreiro, Sylvain Lehmann, Jacques Grassi, Graça Raposo and Jean Luc Darlix
doi: 10.1038/sj.emboj.7601162
The EMBO Journal 25, 2674-2685
Regulation of mitochondrial morphology through proteolytic cleavage of OPA1
Naotada Ishihara, Yuu Fujita, Toshihiko Oka and Katsuyoshi Mihara
doi: 10.1038/sj.emboj.7601184
The EMBO Journal 25, 2966-2977
A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics
Ryo Yonashiro, Satoshi Ishido, Shinkou Kyo, Toshifumi Fukuda, Eiji Goto, Yohei Matsuki, Mari Ohmura-Hoshino, Kiyonao Sada, Hak Hotta, Hirohei Yamamura, Ryoko Inatome and Shigeru Yanagi
doi: 10.1038/sj.emboj.7601249
The EMBO Journal 25, 3618-3626
Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons
Mark J Barsoum, Hua Yuan, Akos A Gerencser, Géraldine Liot, Yulia Kushnareva, Simone Gräber, Imre Kovacs, Wilson D Lee, Jenna Waggoner, Jiankun Cui, Andrew D White, Blaise Bossy, Jean-Claude Martinou, Richard J Youle, Stuart A Lipton, Mark H Ellisman, Guy A Perkins and Ella Bossy-Wetzel
doi: 10.1038/sj.emboj.7601253
The EMBO Journal 25, 3900-3911
Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagy
Susmita Kaushik, Ashish C Massey and Ana Maria Cuervo
doi: 10.1038/sj.emboj.7601283
The EMBO Journal 25, 3921-3933
p97 functions as an auxiliary factor to facilitate TM domain extraction during CFTR ER-associated degradation
Eric J Carlson, David Pitonzo and William R Skach
doi: 10.1038/sj.emboj.7601307
The EMBO Journal 25, 4557-4566
ERp57 is essential for efficient folding of glycoproteins sharing common structural domains
Catherine E Jessop, Seema Chakravarthi, Natalio Garbi, Günter J Hämmerling, Simon Lovell and Neil J Bulleid
doi: 10.1038/sj.emboj.7601505
The EMBO Journal 26, 28-40
Unfolded protein response in a Drosophila model for retinal degeneration
Hyung Don Ryoo, Pedro M Domingos, Min-Ji Kang and Hermann Steller
doi: 10.1038/sj.emboj.7601477
The EMBO Journal 26, 242-252
m-AAA protease-driven membrane dislocation allows intramembrane cleavage by rhomboid in mitochondria
Takashi Tatsuta, Steffen Augustin, Mark Nolden, Björn Friedrichs and Thomas Langer
doi: 10.1038/sj.emboj.7601514
The EMBO Journal 26, 325-335
Lethal recessive myelin toxicity of prion protein lacking its central domain
Frank Baumann, Markus Tolnay, Christine Brabeck, Jens Pahnke, Ulrich Kloz, Hartmut H Niemann, Mathias Heikenwalder, Thomas Rülicke, Alexander Bürkle and Adriano Aguzzi
doi: 10.1038/sj.emboj.7601510
The EMBO Journal 26, 538-547
Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125
Aimin Li, Heather M Christensen, Leanne R Stewart, Kevin A Roth, Roberto Chiesa and David A Harris
doi: 10.1038/sj.emboj.7601507
The EMBO Journal 26, 548-558
Impaired post-translational folding of familial ALS-linked Cu, Zn superoxide dismutase mutants
Cami K Bruns and Ron R Kopito
doi: 10.1038/sj.emboj.7601528
The EMBO Journal 26, 855-866
Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation
N Bhutani, P Venkatraman and A L Goldberg
doi: 10.1038/sj.emboj.7601592
The EMBO Journal 26, 1385-1396
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of A
42
Lisa-Marie Munter, Philipp Voigt, Anja Harmeier, Daniela Kaden, Kay E Gottschalk, Christoph Weise, Rüdiger Pipkorn, Michael Schaefer, Dieter Langosch and Gerd Multhaup
doi: 10.1038/sj.emboj.7601616
The EMBO Journal 25, 3921-3933
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
Ruth Scherz-Shouval, Elena Shvets, Ephraim Fass, Hagai Shorer, Lidor Gil and Zvulun Elazar
doi: 10.1038/sj.emboj.7601623
The EMBO Journal 26, 1749-1760
Endoplasmic reticulum quality control regulates the fate of transthyretin variants in the cell
Takashi Sato, Seiko Susuki, Mary Ann Suico, Masanori Miyata, Yukio Ando, Mineyuki Mizuguchi, Makoto Takeuchi, Mizuki Dobashi, Tsuyoshi Shuto and Hirofumi Kai
doi: 10.1038/sj.emboj.7601685
The EMBO Journal 26, 2501-2512
Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice
Aimin Li, Pedro Piccardo, Sami J Barmada, Bernardino Ghetti and David A Harris
doi: 10.1038/sj.emboj.7601726
The EMBO Journal 26, 2777-2785
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
Dohoon Kim, Minh Dang Nguyen, Matthew M Dobbin, Andre Fischer, Farahnaz Sananbenesi, Joseph T Rodgers, Ivana Delalle, Joseph A Baur, Guangchao Sui, Sean M Armour, Pere Puigserver, David A Sinclair and Li-Huei Tsai
doi: 10.1038/sj.emboj.7601758
The EMBO Journal 26, 3169-3179
J-protein co-chaperone Sis1 required for generation of [RNQ+] seeds necessary for prion propagation
Rebecca Aron, Takashi Higurashi, Chandan Sahi and Elizabeth A Craig
doi: 10.1038/sj.emboj.7601811
The EMBO Journal 26, 3794-3803
The CNS glycoprotein Shadoo has PrPC-like protective properties and displays reduced levels in prion infections
Joel C Watts, Bettina Drisaldi, Vivian Ng, Jing Yang, Bob Strome, Patrick Horne, Man-Sun Sy, Larry Yoong, Rebecca Young, Peter Mastrangelo, Catherine Bergeron, Paul E Fraser, George A Carlson, Howard T J Mount, Gerold Schmitt-Ulms and David Westaway
doi: 10.1038/sj.emboj.7601830
The EMBO Journal 26, 4038-4050
Molecular chaperones and the assembly of the prion Sup35p, an in vitro study
Joanna Krzewska and Ronald Melki
doi: 10.1038/sj.emboj.7600985
The EMBO Journal 25, 822-833
Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis
Tiziana Anelli, Stefania Ceppi, Leda Bergamelli, Margherita Cortini, Silvia Masciarelli, Caterina Valetti and Roberto Sitia
doi: 10.1038/sj.emboj.7601844
The EMBO Journal 26, 4177-4188
Hsp90-mediated cytosolic refolding of exogenous proteins internalized by dendritic cells
Alessandra Giodini and Peter Cresswell
doi: 10.1038/sj.emboj.7601941
The EMBO Journal 27, 201-211
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Gilad Twig, Alvaro Elorza, Anthony J A Molina, Hibo Mohamed, Jakob D Wikstrom, Gil Walzer, Linsey Stiles, Sarah E Haigh, Steve Katz, Guy Las, Joseph Alroy, Min Wu, Bénédicte F Py, Junying Yuan, Jude T Deeney, Barbara E Corkey and Orian S Shirihai
doi: 10.1038/sj.emboj.7601963
The EMBO Journal 27, 433-446