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 VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P2 in yeast and mouse
PI(3,5)P2 plays important roles in intracellular membrane trafficking – in particular in retrograde trafficking from the late endosome/lysosome to the trans-Golgi network. Lois Weisman and colleagues now implicate Vac14 in its control, acting as a scaffold to bring together and organise a large protein complex required for the regulation of PI(3,5)P2 metabolism. |
| Control of WHITE COLLAR localization by phosphorylation is a critical step in the circadian negative feedback process
Yi Liu and colleagues identify protein phosphatase 4 as a novel key component of the Neurospora circadian oscillator, and show the localization of the circadian transcriptional activator, the WHITE COLLAR complex, to be regulated by an interplay of kinases and phosphatases. |
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TGF -stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGF switch
How TGF switches from a potent growth suppressor of normal epithelial cells to a stimulator of migratory and invasive behavior in cancer cells is a major unresolved question. Here, Xiao-Fan Wang and coworkers find that TGF activates, via its cognate ALK5 receptor, Smads normally associated with BMP signaling, providing a shift in the paradigm of TGF signaling in tumor cells. |
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| This collection of eight review articles - Focus on Quality Control - highlights different aspects of cellular quality control and their potential relevance for human diseases. Topics include mitochondrial and ER quality control, protein folding and degradation; as well as quality control in RNA and DNA metabolism. These online review articles include downloadable figures for teaching purposes and links to relevant research articles published recently in The EMBO Journal and other Nature Publishing Group titles. |
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