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 Determination of bacterial rod shape by a novel cytoskeletal membrane protein
Here, Hironori and coworkers identify RodZ as a novel cell shape-determining protein in E. coli. Surprisingly in light of its primary sequence and membrane protein topology, RodZ forms cytoskeletal spirals similar to the bacterial actin homolog MreB, and exhibits a similar loss-of-function phenotype with loss of bacterial rod shape. |
| Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction
The mechanisms linking mechanical stress to ion channel activation are not well understood. Gudermann and colleagues now report that GPCRs, and not TRP ion channels, are the primary mechanosensors in vascular smooth muscle, mediating activation of TRPC channels via intracellular signalling. |
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Identification, structure, and functional requirement of the Mediator submodule Med7N/31
Here, the Cramer lab presents the identification as well as a detailed structure and functional characterisation of a novel submodule in the middle domain of the RNA polymerase II mediator complex, consisting of the highly conserved Med31 subunit and the N-terminal region of Med7. Deletion of the submodule inhibits transcription in vitro, and results in the deregulation of many genes in vivo. |
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| This collection of eight review articles - Focus on Quality Control - highlights different aspects of cellular quality control and their potential relevance for human diseases. Topics include mitochondrial and ER quality control, protein folding and degradation; as well as quality control in RNA and DNA metabolism. These online review articles include downloadable figures for teaching purposes and links to relevant research articles published recently in The EMBO Journal and other Nature Publishing Group titles. |
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