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Welcome to The EMBO Journal

We are pleased to announce our brand new FOCUS on Quality Control. This collection of eight review articles highlights different aspects of cellular quality control and their relevance for human diseases. It includes reviews on mitochondrial and ER quality control, protein folding and degradation, as well as quality control in RNA and DNA metabolism.
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Volume 27, Number 19
(08 October 2008)
ISSN 0261 - 4189
Online ISSN 1460 - 2075
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In this issue
Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii
This paper provides the first molecular understanding of the IRG family of interferon-inducible resistance GTPases. The reported unique case of direct regulatory interaction between two IRG subfamilies provides an explanation for the remarkable degree of functional non- redundancy of these factors in pathogen resistance.
Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells
Constitutive activation of hedgehog signalling has been implicated in human medulloblastoma. In this article Alberto Gulino and coworkers identify three microRNAs that suppress hedgehog signalling and that are downregulated in human medullablastoma.
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Structural basis of cargo membrane protein discrimination by the human COPII coat machinery
Recent EM structures have advanced our understanding of cargo-regulated assembly of COPII vesicles. Six new crystal structures by Mancias and Goldberg now complement this with new insights on how COPII subunits recognize and distinguish cargo signals.
Structure and function of an RNase H domain at the heart of the spliceosome
Prp8 is a highly conserved component of U5 snRNP, thought to play crucial roles in pre-mRNA splicing. New crystal structures from the Luhrmann and Wahl groups, describing Prp8 portions that interact with functional regions of the pre-mRNA, now reveal how Prp8's RNase-like domain may arrange the 5'-splice site and other catalytic RNA residues to facilitate pre-mRNA splicing.
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Focus on quality control
This collection of eight review articles - Focus on Quality Control - highlights different aspects of cellular quality control and their potential relevance for human diseases. Topics include mitochondrial and ER quality control, protein folding and degradation; as well as quality control in RNA and DNA metabolism. The reviews will be printed in three subsequent regular issues of The EMBO Journal starting with the second issue in January 2008 (27.2). These online review articles include downloadable figures for teaching purposes and links to relevant research articles published recently in The EMBO Journal and other Nature Publishing Group titles.
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The EMBO Journal, EMBO reports provides sharply focused short papers and review articles in all areas of molecular biology. Its quality is reflected in its impact factor of 7.45*

* Journal Citation Reports, Thomson Reuters 2008

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