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Journal home Current issue Advance Online Publication Web focuses Archive Browse by subject Free online sample issue Aims and scope Press releases ToC by email Authors & Referees Guide for authors Submit an Article Guide for referees Editorial Team, Senior Advisors and Advisory Editorial Board Contact Editorial office Customer services Subscribe Order sample copy Purchase articles Reprints and permissions Contact NPG Advertising www.embo.org			Web feed Online Submission Volume 27, Number 22 (19 November 2008) ISSN 0261 - 4189 Online ISSN 1460 - 2075 About the cover Register for table of contents by email Recommend The EMBO Journal to your library Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation Ena/VASP proteins are key regulators of actin dynamics, yet conflicting models on their mode of action have been put forward in the literature. The Faix lab now reports the first evidence that VASP delivers actin monomers to the growing barbed end, and thus possesses processive filament elongation activity. A novel disulphide switch mechanism in Ero1 balances ER oxidation in human cells Low reduction potential of Ero1 regulatory disulphides ensures tight control of substrate oxidation Ero1 family members play an essential role in disulphide bond formation in the endoplasmic reticulum (ER), but little is know about the regulation of Ero1 activity in mammalian cells. Two studies from the Ellgaard and Bulleid labs provide new insight into the regulation of human Ero1, revealing a novel regulatory feedback loop in ER redox control. Current issue in full microRNA-122 stimulates translation of hepatitis C virus RNA Very few miRNAs have been found to activate, rather than repress, translation. Michael Niepmann and coworkers now show that the liver-specific miR-122 binds to determinants in the 5'-untranslated region of hepatitis C virus RNA, stimulating its translation by enhancing the association between viral RNA and the small ribosomal subunit. Advance Online Publication in full This collection of eight review articles - Focus on Quality Control - highlights different aspects of cellular quality control and their potential relevance for human diseases. Topics include mitochondrial and ER quality control, protein folding and degradation; as well as quality control in RNA and DNA metabolism. These online review articles include downloadable figures for teaching purposes and links to relevant research articles published recently in The EMBO Journal and other Nature Publishing Group titles. Focus on quality control in full  Journal home  Table of contents  Advanced Online Publication From the organisation that brings you The EMBO Journal, EMBO reports provides sharply focused short papers and review articles in all areas of molecular biology. Its quality is reflected in its impact factor of 7.45* * Journal Citation Reports, Thomson Reuters 2008 science & society  Towards preventive medicine reviews  Functions of poly(ADP-ribosyl)ation scientific reports  Mitochondrial import: Hot13 aids in Mia40 oxidation		23 November 2008 EMBO Resources Fellowships Meetings Science & Society E-BioSci NPG Resources Naturejobs Nature News Signaling Gateway Press office Nature Reports Stem Cells Nature Reports Avian Flu NPG titles by subject

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